Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Hospices Civils de Lyon16 enrolled

Overview

Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Tetraplegia C5-C6 Tetraplegia C6-C7

Interventions

motor imageryPROCEDURE

Intervention consisted of supervised MI during which the participants were trained to imagine performing a single-joint wrist extension movement and a multiple-joint reach-to-grasp movement using tenodesis. The two movements were practiced in separate blocks and each 45 minute MI session consisted of six to eight blocks. Within a given block patients; i) performed the movement once, ii) imagined it using visual imagery (between five and ten repetitions), iii) performed the movement again, and iv) imagined it using kinesthetic imagery (between five and ten repetitions). All movements (performed and imagined) were timed by the experimenter to ensure that the durations of both imagined and physically practiced movements were similar. Imagery vividness was controlled with self-rated assessments using a visual analogic scale (from 0, the image or feeling was absent, to 10 when it was as clear or intense as physical practice).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-55 years old, * quadriplegia elicited by spinal cord injury (SCI) at the C5, C5-C6, C6, or C6-C7 level, * complete infra-lesional motor deficit according to the ASIA impairment scale with finger and forearm flexor muscles paralysis, * post-traumatic period \>6 months (since a motor recovery plateau is usually reached at 6-month post-SCI Exclusion Criteria: * non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension), * cerebral damage and/or cognitive deficit, * elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy, * participation to another study * presence of metallic objects within the body incompatible with MEG or functional magnetic resonance imaging (fMRI) recordings.

Locations (1)

Hôpital Henry Gabrielle - Médecine physique et Réadaptation, Hospices Civils de Lyon, 20 Route de Vourles,

Saint-Genis-Laval, France

Outcomes

Primary Outcomes

Motor imagery ability

Motor imagery ability assessed by magnetoencephalography measurements

Time frame: 10 weeks

Secondary Outcomes

Movement time (MT)

Kinematic parameters of movement: temporal parameters: movement time (MT)

Time frame: 10 weeks

absolute time to peak velocity

Kinematic parameters of movement: temporal parameters: absolute time to peak velocity

Time frame: 10 weeks

movement amplitude at peak velocity

Kinematic parameters of movement: temporal parameters: movement amplitude at peak velocity

Time frame: 10 weeks

time to opening

Kinematic parameters of movement: temporal parameters: time to opening

Time frame: 10 weeks

time to maximal opening

Kinematic parameters of movement: temporal parameters: time to maximal opening

Time frame: 10 weeks

amplitude of maximal opening

Kinematic parameters of movement: temporal parameters: amplitude of maximal opening

Time frame: 10 weeks

Trajectory of movement measured in the XY plane

Kinematic parameters of movement: spatial parameters: Trajectory of movement measured in the XY plane

Time frame: 10 weeks

Data from ClinicalTrials.gov

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