FSH-R : Diagnostic Application for Localized Tumors in Cancerology

Institut Curie95 enrolled

Overview

FRACTal study is the first exploration of detection of FSHR as a blood biomarker for the diagnosis of cancer. A first cohort will explore several common (e.g. breast, prostate) or rare (e.g. uveal melanoma) cancers, that are frequently treated at Institut Curie. This first cohort will include n=10 patients per histological type except for breast cancer (n=50). 100 patients are expected in this cohort. A second cohort will explore the more promising histological type (if any) in term of incidence of detection. 100 patients are expected for this second cohort.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Cancer

Interventions

blood sample for FSHR analysisPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria 1. Patient diagnosed with localized cancer and corresponding to the different types explored. The cancer can be already diagnosed or not (strong suspicion) 2. Age\> 18 3. Written informed consent Exclusion criteria 1. Previous treatment for the tumoral disease 2. Personal history of cancer diagnosis in the last 10 years 3. Pregnant and/or breastfeeding women 4. Person deprived of liberty or under guardianship (including curatorship) 5. psychiatric illness/social situation that would interfere with the protocol or limit compliance with study requirements

Locations (2)

Institut Curie

Paris, France

Centre René Huguenin

Saint-Cloud, France

Outcomes

Primary Outcomes

sensitivity of blood FSH R detection in cancer patients

Time frame: end of the study, up to two years

Secondary Outcomes

variability of blood FSH-R in the same tumoral type and between different tumoral types

Time frame: end of the study, up to two years

comparison of blood FSH-R with blood from healthy donor

Time frame: end of the study, up to two years

Data from ClinicalTrials.gov

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