The purpose of this study is to test the safety and immunogenicity of MVA-BN-Filo and Ad26.Filo as heterologous prime-boost vaccine regimens in healthy adult participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
72
Ad26.Filo intramuscular (IM) injection at a dose of 9\*10\^10 viral particles (vp).
MVA-BN-Filo intramuscular (IM) injection at a dose of 5\*10\^8 infectious units (Inf U).
Ad26.ZEBOV intramuscular (IM) injection at a dose of 5\*10\^10 vp.
Unnamed facility
Rockville, Maryland, United States
Number of Participants With Adverse events (AEs)
Time frame: Up to 28 days after the last vaccination
Number of Participants With Reactogenicity (ie, Solicited Local and Systemic Adverse Events)
Time frame: One Week after each study vaccine administration
Number of Participants With Serious Adverse Events
Time frame: Up to the end of long-term follow-up (Day 360)
Binding Antibody Responses Against Ebola Virus (EBOV), Marburg Virus (MARV), and Sudan Virus (SUDV) Glycoproteins (GPs)
Time frame: Up to Day 360
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IM injection of 0.9 percent saline.
MVA-BN-Filo intramuscular (IM) injection at a dose of 1\*10\^8 Inf U.