A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

Percentage of Participants Free From a Protocol-Defined Event of Disease Activity During 24 Weeks Period

A protocol-defined event of disease activity was defined by the occurrence of at least one of the following while on treatment with ocrelizumab: * A protocol-defined relapse (PDR) * 24-week CDP based on increase in EDSS while on treatment with ocrelizumab * A T1 Gd-enhanced lesion after Week 8 * A new and/or enlarging T2 hyperintense lesion on MRI after Week 8 compared to the Week 8 MRI scan

Time frame: Baseline up to 24 weeks

Percentage of Participants Free From a Protocol-Defined Event of Disease Activity During 48 Weeks Period

A protocol-defined event of disease activity was defined by the occurrence of at least one of the following while on treatment with ocrelizumab: * A protocol-defined relapse (PDR) * 24-week CDP based on increase in EDSS while on treatment with ocrelizumab * A T1 Gd-enhanced lesion after Week 8 * A new and/or enlarging T2 hyperintense lesion on MRI after Week 8 compared to the Week 8 MRI scan

Time frame: Baseline up to 48 weeks

Time to First Protocol-Defined Event of Disease Activity

The definition of a protocol-defined event of disease activity is the occurrence of at least one of the following while on treatment with ocrelizumab: * A protocol-defined relapse defined as: Symptoms must persist for \>24 hours and should not be attributable to confounding clinical factors; Symptoms should be preceded by neurological stability for at least 30 days; Symptoms should be accompanied by new objective neurological worsening determined with a timely EDSS/ Functional Systems Score (FSS) assessment * 24 weeks confirmed disability progression based on increases in EDSS while on treatment with ocrelizumab * A T1 Gd-enhanced lesion after Week 8 * A new and/or enlarging T2 hyperintense lesion on MRI after Week 8 compared to the Week 8 MRI scan.

Time frame: Baseline up to 96 Weeks

Change From Baseline to Week 96 in Expanded Disability Status Scale (EDSS)

The EDSS is an ordinal clinical rating scale ranging from 0 (normal neurologic examination) to 10 (death due to MS) in half-point increments.

Time frame: Baseline, Weeks: 24, 48, 72, 96

Absolute Change From Baseline in EDSS Category at Week 96

The EDSS is an ordinal clinical rating scale ranging from 0 (normal neurologic examination) to 10 (death due to MS) in half-point increments.

Time frame: Up to Week 96

Percentage of Participants With a Baseline EDSS Score ≥2 With CDI at Week 96

The EDSS is an ordinal clinical rating scale ranging from 0 (normal neurologic examination) to 10 (death due to MS) in half-point increments.

Time frame: Week 96

Annualized Protocol-defined Relapse Rate at Week 96

Time frame: Week 96

Time to Onset of 24-week Confirmed Disability Progression

Time frame: Baseline up to 96 Weeks

Time to Onset of First Protocol-Defined Relapse

A protocol-defined multiple sclerosis (MS) relapse is an occurrence of new or worsening neurological symptoms attributable to MS that meets the following criteria: * Symptoms must persist for \>24 hours and should not be attributable to confounding clinical factors (e.g., fever, infection, injury, adverse reactions to medications) * Symptoms should be preceded by neurological stability for at least 30 days * Symptoms should be accompanied by new objective neurological worsening determined with a timely EDSS/ Functional Systems Score (FSS) assessment, consistent with an increase of at least: * ≥ 0.5 points on EDSS scale * or ≥ 2 points on one of the following FSS scales: pyramidal, ambulation, cerebellar, brainstem, sensory, or visual * or ≥ 1 point on two or more of the following FSS scales: pyramidal, ambulation, cerebellar, brainstem, sensory, or visual

Time frame: Baseline up to 96 Weeks

Time to Onset of First New and/or Enlarging T2 Lesion

Time frame: Baseline up to 96 Weeks

Mean Number of T1 Gd-enhancing Lesions Per MRI Scan at Weeks 24, 48 and 96

Mean number of T1 Gd-enhancing lesions per MRI scan: Total number of T1 Gd-enhanced lesions divided by the total number of interpretable MRI scans

Time frame: Weeks: 24, 48, 96

Change From Baseline to Week 96 in Total T2 Lesion Volume Detected by Brain MRI From

Time frame: Baseline, Week 96

Percentage Change From Baseline to Week 96 in Total T2 Lesion Volume Detected by Brain MRI

Time frame: Baseline, Week 96

Volume of New and/or Enlarging T2 Hyperintense Lesions Volume of Lesions Per MRI Scan at Weeks 24, 48, 96

The number of new and/or enlarging T2 lesions at week 24, 48 and 96 is calculated as the sum of the individual number of new and/or enlarging lesions at each visit. Data from other unscheduled assessments is included in this summary or analysis.

Time frame: Weeks 24, 48, 96

Mean Number of New and/or Enlarging T2 Hyperintense Lesions Per MRI Scan

Mean number of new and/or enlarging T2 hyperintense lesions per MRI scan: Total number of new and/or enlarging T2 hyperintense lesions divided by the total number of interpretable MRI scans

Time frame: Weeks 24, 48, 96

Change From Baseline at Week 48 and 96 in T1 Hypointense Lesion Volume

Time frame: Weeks 48, 96

Percentage Change From Baseline at Week 48 and 96 in T1 Hypointense Lesion Volume

Time frame: Weeks 48, 96

Adjusted Mean Change From Baseline at Week 48 and 96 in T1 Hypointense Lesion Volume

Time frame: Weeks 48, 96

Adjusted Mean Percentage Change From Baseline in Brain Volume

Time frame: Weeks 24, 48, 96

Adjusted Mean Percentage Change From Baseline in Cortical Grey Matter Volume

Time frame: Weeks 48, 96

Adjusted Mean Percentage Change From Baseline in White Matter Volume

Time frame: Weeks 48, 96

Mean Change From Baseline in Cognitive Performance (Processing Speed/Working Memory) at Week 48 and Week 96 as Measured by the Brief International Cognitive Assessment for MS - Symbol Digit Modalities Test (SDMT) Score

Brief International Cognitive Assessment for MS (BICAMS) is assessing cognitive processing speed and verbal and visual memory. Symbol Digits Modalities Test (SDMT) is assessing processing speed/working memory. The SDMT presents a series of nine symbols, each paired with a single digit in a key at the top of a standard sheet of paper. Participants are asked to voice the digit associated with each symbol as rapidly as possible for 90 sec. There is a single outcome measure - the number correct over the 90 sec time span. The higher the results, the better processing speed/working memory.

Time frame: Baseline, Weeks: 48, 96

Change From Baseline in Cognitive Performance (Visuospatial Memory) at Week 48 and Week 96 as Measured by the Brief International Cognitive Assessment for MS - Brief Visuospatial Memory Test-Revised (BVMT-R) Score

Brief International Cognitive Assessment for MS (BICAMS) is assessing cognitive processing speed and verbal and visual memory. Brief Visuospatial Memory Test-Revised (BVMT-R) is assessing visuospatial memory. In this test, six abstract designs are presented for 10 sec. The display is removed from view and patients render the stimuli via pencil on paper manual responses. Each design receives from 0 to 2 points representing accuracy and location. There are three learning trials, and the outcome measure is the total number of points earned over the three learning trials, thus the scale range is 0-36. The higher the result, the better visual/spatial memory.

Time frame: Baseline, Weeks 48, 96

Percentage Change From Baseline in Cognitive Performance (Processing Speed/Working Memory) at Week 48 and Week 96 as Measured by the Brief International Cognitive Assessment for MS - Symbol Digit Modalities Test (SDMT) Score

Brief International Cognitive Assessment for MS (BICAMS) is assessing cognitive processing speed and verbal and visual memory. Symbol Digits Modalities Test (SDMT) is assessing processing speed/working memory. The SDMT presents a series of nine symbols, each paired with a single digit in a key at the top of a standard sheet of paper. Participants are asked to voice the digit associated with each symbol as rapidly as possible for 90 sec. There is a single outcome measure - the number correct over the 90 sec time span.

Time frame: Baseline, Weeks 48, 96

Percentage Change From Baseline in Cognitive Performance (Visuospatial Memory) at Week 48 and Week 96 as Measured by the Brief International Cognitive Assessment for MS - Brief Visuospatial Memory Test-Revised (BVMT-R) Score

Brief International Cognitive Assessment for MS (BICAMS) is assessing cognitive processing speed and verbal and visual memory. Brief Visuospatial Memory Test-Revised (BVMT-R) is assessing visuospatial memory. In this test, six abstract designs are presented for 10 sec. The display is removed from view and patients render the stimuli via pencil on paper manual responses. Each design receives from 0 to 2 points representing accuracy and location. There are three learning trials, and the outcome measure is the total number of points earned over the three learning trials, thus the scale range is 0-36. The higher the result, the better visual/spatial memory.

Time frame: Baseline, Weeks: 48, 96

Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

Time frame: Baseline up to to 96 weeks after the end of the Treatment Period