Intravenous Dexamethasone for Ropivacaine Axillary Block

Centre Hospitalier Universitaire de Besancon99 enrolled

Overview

Prospective monocentric double-blind controlled randomised trial Aim is to assess prolonged postsurgical analgesia by intravenous dexamethasone versus intravenous placebo, after ultrasound guided axillary brachial plexus block

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain Anesthesia Forearm Injuries

Interventions

intravenous dexamethasoneDRUG

intravenous injection of dexamethasone

intravenous placeboDRUG

intravenous injection of placebo

perineural ropivacaineDRUG

brachial plexus block with perineural injection of Ropivacaine in the axillary fossa

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA 1,2 et 3 * surgery under axillary brachial plexus block * aged \>18 years * signed information consent Exclusion Criteria: * impaired coagulation * contraindication to regional anesthesia or technical impossibility * opioids or pain killers abuse or addiction * steroids consumption in the past 6 months * dementia or under administrative supervision * delay of surgery to short to allow regional anesthesia * pregnancy and breastfeeding * allergy and contraindication to dexamethasone or ropivacaine * anticipated bad observation of treatment * patient enrolled in another trial

Locations (1)

CHRU de Besancon

Besançon, France

Outcomes

Primary Outcomes

Analgesia duration after axillary brachial plexus block

Time frame: time to first pain at surgical site, an average of 24 hours

Secondary Outcomes

Motor block duration after axillary brachial plexus block Safety

Time frame: up to block recovery, an average of 24 hours

Sensory block duration after axillary brachial plexus block

Time frame: up to block recovery, an average of 24 hours

incidence of adverse event

Time frame: 6 month

Data from ClinicalTrials.gov

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