Analgesia for Endometrial Scratching

University of Sao Paulo150 enrolled

Overview

The aim of this study is to evaluate whether Ibuprofen alone or combined with lorazepam reduce the pain associated with endometrial scratching/injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

150

Conditions

Subfertility Infertility

Interventions

Ibuprofen 600 mgDRUG

Lorazepam 1 mgDRUG

PlaceboDRUG

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women aged ≥ 18 years undergoing assisted reproduction (IUI, IVF/ICSI, frozen embryo transfer) * Being submitted to endometrial scratching/injury with a Pipelle on the first four days of the menstrual cycle. * Not have performed endometrial scratching in the last 90 days. Exclusion Criteria: \- None

Outcomes

Primary Outcomes

Maximum pain during procedure

Evaluated by both visual analog scale (10 cm) and numeric verbal scale (0 to 10).

Time frame: 5 minutes

Secondary Outcomes

Pain after the procedure

Evaluated by both visual analog scale (10 cm) and numeric verbal scale (0 to 10).

Time frame: 5 minutes

Rejection to a new procedure

Evaluated by a 5-point Likert scale, commenting on this sentence: "I would repeat this procedure if it were indicated". 1 = I fully agree; 2 = I agree; 3 =Neither agree nor disagree; 4 = Disagree; 5 = Strongly Disagree.

Time frame: 5 minutes

Data from ClinicalTrials.gov

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