Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver Disease

Humanity and Health Research Centre1,500 enrolled

Overview

The purpose of this study is to determine the disease progression in CHB/NAFLD compared with CHB and NAFLD including liver cirrhosis, cirrhotic complications and hepatocellular carcinoma (HCC).

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Chronic Hepatitis B Nonalcoholic Fatty Liver Disease

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Liver biopsy proved CHB and/or NAFLD at baseline; * Chinese * Follow-up duration\>12 months Exclusion Criteria: * Other liver diseases; * Secondary causes of hepatic steatosis; * Alcohol abuse; * Liver cirrhosis, cirrhosis related complications or HCC at baseline; * Malignancy; * History of liver transplantation

Locations (1)

Humanity and Health GI and Liver Centre

Hong Kong, Hong Kong, China

RECRUITING

Outcomes

Primary Outcomes

Number of patients with liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma

Time frame: Up to 20 years

Secondary Outcomes

Number of patients with hypertension, obesity, diabetes mellitus, hyperlipidaemia

Time frame: Up to 20 years

Number of patients with liver transplantation and liver-related death

Time frame: Up to 20 years

Diagnosis time of liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma from baseline

Time frame: Up to 20 years

Occurrence time of liver transplantation and liver-related death from baseline

Time frame: Up to 20 years

Central Contacts

George Lau, MD

CONTACT

+852 2861 3777 gkklau@netvigator.com

Data from ClinicalTrials.gov

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