Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia

Inclusion Criteria: * Patients with critical lower limb ischemia, with resting pain wich can't be adequately managed by opioid analgetics and/or foot ulcers or necrosis, with II-4, III-5 и IV-6 stages of chronic arterial failure according to Rutherford's classification * Ankle-brachial index less than 0.4 and/or ТСрО2 less than 30 mm Hg * Patients with lower limbs' arteries lesions revealed by angiography uneffectiveness or impossibility of limb's revascularisation or patient's refusal of the procedure * Patient is familiar with Participant information sheet * Patient signed informed consent form Non-inclusion Criteria: * Contraindications for local anesthesia or history of allergy for local anesthetics * Systemic glucocorticoid and/or immunosuppressant therapy * Any condition that might limit compliance (dementia, mental disorders, narcotic drug or alcohol abuse etc.) * Participation in other clinical trials (or administration of investigational drugs) during 3 months prior inclusion * Patients with malignant tumors including postoperative period, patients receiving chemotherapy and/or radiotherapy * Clinically significant abnormalities in results of laboratory tests * Patient received anticoagulants at least 12 hours prior the liposuction * Medical history of heterotopic ossifications * Patients prescribed for glycoprotein inhibitors treatment Exclusion Criteria: * Patient's refusal from the further participation in trial * Chronic kidney disease IV- V stages (creatinine clearance \< 30 mL/min estimated by Cockcroft-Gault formula) * Confirmed syphilis, HIV, hepatitis B or C infections Dropout Criteria: * Indications for the amputation of the limb