Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer

Inclusion Criteria: * Each patient must be positive for HLA-A\*02 and meet all of the following inclusion criteria to be enrolled in the study: * Histologically or cytologically proven HPVOC or cervical cancer or anal cancer, based on expression of HPV type16 in immunohistochemistry and/or HPV 16 DNA analysis by ISH of tumor tissue from the primary or metastatic lesions. * Incurable HPVOC, as defined by: * Relapsed or progressive disease at the primary site and/or regional lymph nodes after initial treatment (e.g. Surgery, radiotherapy or chemoradiotherapy) with no potentially curative option (i.e. surgery or radiation); OR * Distant metastasis * Incurable cervical or anal cancer, as defined by: * Relapsed or progressive disease at the primary site and/or regional lymph nodes after initial treatment (e.g. systemic chemotherapy) with no potentially curative option (i.e. surgery or chemoradiotherapy). Chemotherapy administered in conjunction with primary radiation as a radiosensitizer will not be counted as a systemic chemotherapy regimen; OR * Distant metastasis refractory to initial treatment (at least one prior chemotherapeutic regimen which can include a single chemotherapeutic, a combination of chemotherapeutics, or biologic drugs such as bevacizumab). * Accessible tumors for sequential biopsies Terminology Criteria for Adverse Events Version 4.0 (CTCAE v4.03) to grade 1 or better (except for \< grade 2 neuropathy, alopecia, xerostomia, dysphagia, or mucositis); * Age ≥ 18 years; * Measurable disease, according to modified RECIST 1.1 and irRECIST (Appendix B \& C); * Eastern Cooperative Oncology Group performance status (ECOG PS) ≤ 2 (Appendix A) * Adequate bone marrow, liver and renal function, defined by: * Hemoglobin ≥ 10 g/dL; * Absolute neutrophil count (ANC) ≥ 1000/μL; * Absolute lymphocyte count ≥ 400/μL; * Platelet count ≥ 100,000/μL; * ALT and AST ≤ 2.5 X upper limit of normal (ULN); * Total bilirubin ≤ 1.5 X ULN; and * Serum creatinine ≤ 1.5 X ULN; * Women of child-bearing potential (WOCBP) must be willing to use acceptable means of birth control; * Men who could potentially father a child must also use birth control * Signed informed consent Exclusion Criteria: * Radiotherapy for primary HPVOC within 8 weeks, or radiotherapy for any other reason within 3 weeks prior to the first dose of trial treatment; * Chemotherapy within 3 weeks prior to the first dose of trial treatment;Other cancer in the past 5 years, except for carcinoma in situ of the cervix or bladder, or non-melanomatous skin cancer; * Inaccessible tumor or lack of consent for sequential biopsies * Uncontrolled central nervous system (CNS) metastases (i.e. known CNS lesions that are radiographically unstable, symptomatic and/or requiring escalating doses of corticosteroids); * Active hepatitis, known HIV, or other condition that requires immunosuppressive therapy, including current use of high dose systemic corticosteroids; * Autoimmune disease, such as systemic lupus erythematosis or rheumatoid arthritis, that is active and requires current immunosuppressive therapy; * Active uncontrolled serious infection; * WOCBP who have a positive β-hCG test or are breastfeeding. * Acute or chronic skin disorders that would interfere with subcutaneous injection of the vaccine or subsequent assessment of potential skin reactions; * Allergies to any vaccine, that after discussion with Immunovaccine, are serious enough to warrant exclusion from this study