Transpulmonary Pressure and Airway Pressure Release Ventilation (APRV).

Assistance Publique Hopitaux De Marseille20 enrolled

Overview

Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure. The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Patient Mechanically Ventilated With APRV Mode

Interventions

evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.OTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult * Patient mechanically ventilated for more than 48 H for acute respiratory failure * Decision to use of the APRV mode by clinicians in charge of the patient Exclusion Criteria: \- Contraindication for the use of a nasogastric tube

Locations (1)

Assistance Publique Hôpitaux de Marseille hôpital de la Timone

Marseille, France

Outcomes

Primary Outcomes

Transpulmonary pressure

Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.

Time frame: 24 hours

Secondary Outcomes

Maximal value of transpulmonary pressure

Value of tidal volume \> 8 ml/kg

Time frame: 24 hours

Data from ClinicalTrials.gov

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