Dose-response Effects of Soybean Oil in Salad Dressing on Carotenoid/Fat-soluble Vitamin Bioavailability in Salad Vegetables

Iowa State University

Overview

The objectives will be to evaluate the dose-response between the amount of soybean oil in salad dressing and the absorption of: 1) carotenoids, phylloquinone, and tocopherols in salad vegetables; 2) retinyl palmitate formed from the provitamin A carotenoids, alpha- and beta-carotene.

Study Type

INTERVENTIONAL

Conditions

Biological Availability

Interventions

Soybean oil in salad dressingOTHER

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * General good health as determined by interview, blood biochemistry profile, complete blood count, and plasma lipid and lipoprotein profile Exclusion Criteria: * Cigarette smoking, frequent alcohol consumption * Use of vitamin/mineral supplements * Lactose intolerance * Known food allergies * Body mass index (BMI) 30 or higher * Eating disorder or restrained eating * Vegetarianism * Hyperlipidemia * Current or planned pregnancy * Use of hormonal contraceptives (affects chylomicron clearance); use of plant sterols or medications known to affect lipid metabolism

Outcomes

Primary Outcomes

Area under the curve for carotenoids, phylloquinone, tocopherols, and retinyl palmitate in the plasma chylomicron fraction

Time frame: 0-9.5 hours postprandially

Data from ClinicalTrials.gov

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