Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study

Inclusion Criteria: * Glasgow Coma Score of 13-15; * one or more of the following: loss of consciousness (if present) \< 30 min, post-traumatic amnesia (if present) \< 24 h, and/or other transient neurological abnormalities such as focal signs, seizure, and intracranial lesion not requiring surgery. * no contraindications to MRI; * injury within 7 days; * agreement to communicate by telephone or e-mail for 1, 3 to 6-12 months after enrollment and come back to the hospital for follow-up Exclusion Criteria: * history of neurological disease * head injury, or history of substance or alcohol abuse, intubation and/or presence of a skull fracture * administration of sedatives on arrival in the emergency department * spinal cord injury, manifestation of mild TBI due to other injuries (e.g., systemic injuries, facial injuries, or intubation) or other problems (e.g., psychological trauma, language barrier, or coexisting medical conditions), or caused by penetrating craniocerebral injury.