A Study to Determine the Role of Toll-like Receptor-4 Expression in Patients With Interstitial Cystitis/Bladder Pain Syndrome

Inclusion Criteria: 1. Patients must be a candidate for cystoscopy, hydrodistention and bladder biopsy. 2. Participant must have subjective complaints of 1. urinary urgency, relieved with voiding, OR 2. urinary frequency; ≥ 8 voids per day, OR 3. pelvic pain, pressure, or discomfort 2\. Gender of subjects: Subjects in this study will be female. Pregnant women and breastfeeding women will be excluded due to unknown risk of study medication on pregnancy and fetus or nursing infants. 3\. Age of subjects: Age of subjects will range from 18 to 90 years. 4\. Racial and ethnic origin: There are no enrollment restrictions based upon race or ethnic origin. The racial and ethnic distribution of subjects is entirely based on the population of patients at the study site. 5\. Other inclusion criteria: 1. Participant must give written informed consent to participate in the study 2. Participant must be able to make decisions for herself 3. Participant must not have had a UTI within 7 days prior to start of the study 4. Female participants who are with a positive pregnancy test Exclusion Criteria: To participate in the study subjects must not meet any of the following criteria: 1. Participant is currently pregnant or breastfeeding 2. Participant has a positive urinary pregnancy test at the time of screening 3. Participant is currently or has been on antibiotic therapy with the last 7 days prior to the start of the study 4. Participant is currently in another trial 5. Participant has an active S3 nerve stimulator implanted or has PTNS 6. Participant has had intravesical botulinum toxin injection in 6 months prior to starting the study 7. Participant has grade III or IV pelvic organ prolapse 8. Participant has history of bladder cancer 9. Participant has a neurological disease including, but not limited to, multiple sclerosis, Parkinson's disease, Alzheimer's disease, spinal cord injury, brain injury, stroke or dementia 10. Participant has urinary frequency of less than 8 times/day 11. Participant has bladder or lower ureteral calculi 12. Participant has active genital herpes 13. Participant has urethral diverticulum 14. Participant has chemical cystitis 15. Participant has radiation or tuberculosis cystitis