Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia

University Hospital, Strasbourg, France162 enrolled

Overview

The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways. The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects. The coherence between structural and functional anomalies will be especially studied.

Study Type

OBSERVATIONAL

Enrollment

162

Conditions

Schizophrenia Catatonia

Interventions

Quantitative multiparametric and functional MRIOTHER

Structural connectivity assessed in the cortex and the white matter using multimodal quantitative parametric imaging (R1, R2, R2\*, DTI, susceptibility, macromolecular proton fraction, cortical thickness, VBM). Functional connectivity assessed using simple BOLD and combined ASL-BOLD sequences during multiple tasks including motor, language and working memory tasks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria (controls): * Aged from 18-65 Y * Right handed Additional inclusion criteria for patients: * Schizophrenia according to the DSM5 * Either periodic catatonia or cataphasia according to the WKL classification * Under stable medication regimen (\> 1M) Exclusion criteria: * Current substance abuse * Contraindication to MRI * Past records susceptible to affect brain integrity * Severe, unstable medical condition * Pregnancy * Patients deprived of their rights

Outcomes

Primary Outcomes

Changes in structural and functional connectivity according to the phenotype. Correlation between these changes

Statistical parametric mapping (SPM) will be applied on quantitative maps : rCBF (ml/100g/min), susceptibility (part per billion), R1, R2, R2\* (all expressed in ms-1), fractional anisotropy (fraction), averaged diffusivity (μm²/sec), macromolecular proton fraction (percentage), cortical thickness (mm), VBM (probability of grey and white matter) and contrast maps (BOLD signal correlation with the anterior cingulate ROI).

Time frame: Subjects will be assessed only once.

Secondary Outcomes

Changes in rCBF and cognition according to the phenotype. Correlation between the different changes and the symptomatic scales.

Symptomatic scales : PANSS, SANS, SAPS, Calgary, Bush and Francis catatonia scale, the psychological experimental test operationalized for cataphasia, Clinician-rated dimension of psychosis symptom severity questionnaire assessing handedness, anhedonia, vigilance, QoL, activity, handicap, ruminations, depression and personality. Cognitive tests : grammar tests, semantic priming, implicit memory, CPT, fNART, Mill-Hill (part B)