Strain X Cardiopulmonary Test

Daniella Cunha Brandao26 enrolled

Overview

Introduction : Patients with heart failure (HF ) with systolic dysfunction of moderate to severe exhibit significant reduction in the ability to exercise compared to those with mild dysfunction , and have worse prognosis. However, some clinical markers of severity and diagnosis widely used in this population such as ejection fraction (EF) , are not always able to translate the actual degree of cardiac damage as well as their relationship with the cardiorespiratory fitness of these individuals and prognosis . Objective: To evaluate the ability of the global longitudinal strain ( GLS ) in predicting exercise tolerance in heart failure patients with moderate and significant systolic dysfunction.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure

Eligibility

Sex: ALLMin age: 21 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * moderate and significant systolic dysfunction (LVEF \< 45%) assessed by transthoracic echocardiography recent ( last month before evaluation ) Teichholz method , or when in the presence of contractile deficit target , by the Simpson method. Exclusion Criteria: * deformity in the face to prevent the coupling of the mask to perform the CPET , * orthopedic and neurological diseases that could make it impossible to perform the tests , * patients with psychiatric disorders that restricted them to respond to the questionnaire , * HF FC IV or hospitalization in the last three months , * angina unstable; * myocardial infarction or heart surgery up to three months before the survey ; * FEV1 / FVC \<70 % predicted characterizing obstructive respiratory disorder .

Locations (1)

Universidade Federal de Pernmabuco

Recife, Pernambuco, Brazil

RECRUITING

Outcomes

Primary Outcomes

Echocardiography for obtaining the "strain "

To strain of technical analysis will be used echocardiography analysis software ( EchoPAC , GE Medical Systems, Horten , Norway, version 10.0 ) . The images will be analyzed in the longitudinal sections ( 4 bedrooms , 3 bedrooms and 2 cameras) . The endocardium is drawn manually from the septum to the lateral mitral annulus. A region of interest will be applied automatically by the software.

Time frame: 1 day

Secondary Outcomes

Cardiopulmonary Test

Cardiopulmonary exercise testing will be carried out by the treadmill ramp method ( Centurium 300 , Micromed , Brazil ) through ErgoPC Elite® software associated with the electrocardiogram ( Micromed , Brazil ) with 12 channels. Respiratory variables will be evaluated by a gas analyzer ( Cortex - Metalyzer II , Germany) being obtained in standard conditions of temperature , pressure and humidity ( STPD ) , breath - by - breath , with the patient breathing in a face mask without leaks during exercise. Will be assessed during the test , functional capacity , measured in METs , VO2 , VE / VCO 2 , VE / VCO 2 slope , T1 / 2VO2 and RFC1 .

Time frame: 1 day

Central Contacts

Daniella C Brandão, pHD

CONTACT

+558121268000 daniellacunha@hotmail.com

Data from ClinicalTrials.gov

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