Correlation Between PET and Advanced MRI in Multiple Sclerosis

University of British Columbia14 enrolled

Overview

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific. This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria. * Aged 18 to 60 * High or mixed affinity binder to rs6971 TSPO polymorphism Exclusion Criteria: * Pregnant or breastfeeding * Suffering from an unstable medical condition * Have a neurological or ocular disorder other than MS * Any contra-indications to MRI

Locations (1)

MS Clinical Trials Group - UBC

Vancouver, British Columbia, Canada

Outcomes

Primary Outcomes

Whole Brain PBR28 binding

Time frame: Baseline

Secondary Outcomes

Lesional PiB binding

Time frame: Baseline

Myelin Water Imaging

Time frame: Baseline

MR Spectroscopy (Total NAA, NAA/Cr, mI)

Time frame: Baseline

Optical Coherence Tomography (RNFL thickness)

Time frame: Baseline

Data from ClinicalTrials.gov

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