Docetaxel is widely used in oncology for the treatment of many solid tumors. The side effects of docetaxel are many and sometimes serious. The primary toxicity of docetaxel is neutropenia. Skin and nail manifestations, frequency, the second category of adverse events after haematological adverse events. Use of the product Evonail® was demonstrated in a patient treated by doxetaxel and having nail damage. The purpose of this study is to confirm the effectiveness of the film-forming solution Evonail® versus a placebo on the prevention of nail damage in women with breast cancer and treated by adjuvant docetaxel.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
50
film-forming solution containing water Evaux naturally rich in lithium, strontium and manganese with UV filter
film forming excipient solution
Institut de Cancerologie de Lorraine
Vandœuvre-lès-Nancy, France
Efficacy of the film-forming solution Evonail® versus placebo on nail damage
Efficacy will be evaluated by the oncologist according to NCI-CTC
Time frame: up to 9 weeks
Different types of nail damage observed in each group after chemotherapy docetaxel
Nail damage will be evaluated by the dermatologist based on photography according to NCI-CTC
Time frame: up to 9 weeks
Patient compliance for the film-forming solution Evonail®
Patient compliance will be evaluated using a questionnaire
Time frame: up to 9 weeks
Patient satisfaction regarding the use of the film-forming solution Evonail®
Patient satisfaction will be evaluated using a questionnaire
Time frame: up to 9 weeks
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