Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K

Inclusion Criteria: 1. Age ≥ 45 years and less than 80 years 2. At least 12 months on Hemodialysis 3. Coronary artery calcium score of ≥ 30 in the baseline Multislice Computed Tomography 4. Able to give informed consent 5. Life expectancy of at least18 months Exclusion Criteria: 1. History of thrombosis in the last 6 months except vascular access thrombosis 2. Need for vitamin K antagonists therapy at baseline or in the 3 months prior to baseline 3. Presence of significant gut disease (inflammatory bowel disease, short-bowel syndrome) 4. Liver dysfunction 5. Alcohol or drug abuse 6. Presence of coronary stent or have undergone coronary artery bypass grafting 7. Women who are pregnant or breast feeding, 8. Those who are fearful of confined space and cannot lie still for Multislice Computed Tomography 9. Lack of safe contraceptive measures. 10. Those who had parathyroid surgery done. 11. Those with parathyroid hormone (PTH) \> 150 pmol/l 12. Patient taking multivitamins containing vitamin K 13. Patient allergic to soy based products