Fraction of Inspired Oxygen and Atelectasis in Children

Seoul National University Hospital86 enrolled

Overview

Investigators hypothesized that maintaining low fraction of inspired oxygen would be beneficial to prevent anesthesia-induced atelectasis in mechanically ventilated children undergoing general anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Pulmonary Atelectasis

Interventions

Lung ultrasoundDEVICE

Lung ultrasound on both hemithorax in supine position

Respiratory managementOTHER

Appropriate respiratory managements depending on the lung ultrasound findings

Eligibility

Sex: ALLMax age: 7 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Expected operation time between 1 to 3 hours under general anesthesia * Mechanically ventilated after endotracheal intubation Exclusion Criteria: * Cardiac, thoracic, abdominal surgery * History of surgery on the lungs * Laparoscopic surgery * Abnormal preoperative chest radiograph findings including atelectasis, pneumothorax, pleural effusion, and pneumonia * Considered inappropriate by the investigator

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Incidence of postoperative atelectasis

Time frame: within the first day after the surgery

Secondary Outcomes

Incidence of atelectasis after endotracheal intubation

Time frame: from the moment of endotracheal intubation until the end of surgery, up to 4 hours

Intraoperative incidence of pulse oximetry (SpO2) ≤ 95% (or 10% below the baseline value)

Time frame: from the induction of general anesthesia until the end of the surgery, up to 4 hours

Postoperative incidence of pulse oximetry (SpO2) ≤ 95% (or 10% below the baseline value)

Time frame: within the first day after the surgery

Postoperative incidence of fever (≥37.5℃)

Time frame: within the first day after the surgery

Postoperative incidence of respiratory complications

Time frame: within the first day after the surgery

Data from ClinicalTrials.gov

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