Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis

Southeast University, China124 enrolled

Overview

Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

124

Conditions

28-day Mortality Sepsis

Interventions

BNP and NGALOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥18 years and \<85 years; * presence of severe sepsis according to Survival Sepsis Campaign 10; * all patients voluntarily joined this study with informed consents. Exclusion Criteria: * participated in other trials within 30 days before the criteria for this trial were met; * expected to die within 24 hours; * pregnant; * advanced malignancy with life expectancy \<6 months; * history of congestive heart failure; * chronic renal dysfunction (baseline creatinine \>176.8μmol/L); and * relatives were unwilling to agree to the use of full life support.

Outcomes

Primary Outcomes

patient-ventilator synchrony for 30mins

Time frame: 30mins after the patients involved

Secondary Outcomes

the numbers of days in the ICU between day 1 and day 28

Time frame: the numbers of days in the ICU until day 28

Mechanical ventilation duration between day 1 and day 28

Time frame: days of mechanical ventilation between day 1 and day 28

28-day mortality

Time frame: 28 days after the patients involved

Data from ClinicalTrials.gov

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