A Study to Evaluate the Safety and Tolerability of Valproic Acid in Trauma Patients(Part 2)

Inclusion Criteria: 1. Male and non-pregnant female trauma patients between the ages of 18-70 years, inclusive. 2. Blunt or penetrating trauma resulting in two or more systolic blood pressure readings of ≤ 110 mmHg at any point during transport to the hospital or within the first hour after arrival in the emergency department. Systolic blood pressure readings of ≤ 110 mmHg need not be consecutive (Eastridge et al., 2007). 3. Patient's admission to the emergency department results in trauma team activation (per institutional criteria, see Appendix 7). 4. Patient's injuries are considered potentially survivable by the attending trauma surgeon on initial evaluation. 5. Able to provide informed consent or consent can be obtained from a representative (spouse or other legally authorized representative) in the event that the subject is unconscious or otherwise impaired. 6. Female subjects must be postmenopausal, surgically sterilized, or have a negative urinary pregnancy test on arrival. Criteria for menopause include age \> 45 with absence of menses for \> 12 months. Criteria for surgical sterilization include hysterectomy and/or oophorectomy. Tubal ligation with menses within the past 12 months is not considered to be surgical sterilization. 7. Body mass index (BMI) between 18 kg/m2 and 35 kg/m2 Exclusion Criteria: 1. Subjects with known history of adverse reaction to Valproic acid. 2. Subjects with known history of hepatitis B or C or clinical history of hepatic dysfunction, pancreatitis, or renal insufficiency. 3. Subjects with -amylase \>400 U/L or lipase \>300 U/L or creatinine \>ULN 4. Subjects with AST or ALT \>3X Upper limit of normal (ULN) or total bilirubin \>1.5X Upper limit of normal (ULN) 5. Subjects with 2nd or 3rd degree burns of any size and location. 6. Female subjects who are pregnant or lactating. 7. Subjects who are currently incarcerated. 8. Subjects with severe traumatic brain injury (with Glasgow Coma Scale score \<8 on arrival to the emergency department). 9. Non-hemorrhagic causes of shock, including septic, cardiogenic, or neurogenic shock or mechanical reasons such as tension pneumothorax or cardiac temponade. 10. Subjects with inadequate venous access. 11. Subject with a hemoglobin level of less than 8g/dL. \-