Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

Kayseri Education and Research Hospital40 enrolled

Overview

The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Apoptotic Signal Pathways in Endometrial Hyperplasia

Interventions

17β estradiol hemihydrateDRUG

4mg/kg/day for 20 days

MetforminDRUG

50 mg/kg/day last 10 days

medroxyprogesterone acetateDRUG

1mg/kg/day last 10 days

Eligibility

Sex: FEMALEMin age: 8 WeeksMax age: 10 Weeks

Medical Language ↔ Plain English

Inclusion criteria: Forty-eight weeks old female Wistar-Albino rats, weighting between 180 and 260 g Exclusion criteria. We have no exclusion criteria because we examine drugs effects in the experimental rats

Locations (1)

Kayseri Training and Research Hospital

Kayseri, Turkey (Türkiye)

Outcomes

Primary Outcomes

Survivin Gene Expression Levels in Rat Uterine Tissue

Time frame: 4 months

Bcl-2 Gene Expression Levels in Rat Uterine Tissue

Time frame: 4 months

Bax Gene Expression Levels in Rat Uterine Tissue

Time frame: 4 months

c-Myc Gene Expression Levels in Rat Uterine Tissue

Time frame: 4 months

Caspase-9 Expression Levels in Rat Uterine Tissue

Time frame: 4 months

Data from ClinicalTrials.gov

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