High Dose Vitamin D Supplementation in Chronic Spontaneous Urticaria

Shiraz University of Medical Sciences80 enrolled

Overview

Chronic spontaneous urticaria is an inflammatory disease which is characterized with intermittent or daily urticaria. This diseases lasts for more than 6 weeks. Several recent studies have suggested a role for vitamin D in modulation of immune system and pathogenesis of chronic urticaria.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Urticaria

Interventions

Vitamin D3 (High dose)DRUG

Daily 4000 unites vitamin D

Vitamin D3 (Low dose)DRUG

Daily 600 unites vitamin D

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Uriticaria or angioedema daily or more than 3 days a weeks for at least 6 weeks Exclusion Criteria: * Physical urticaria aquired or hereditary angioedema Calcium level \> 10.3 mg/dl Glomerular filtration rate \<50 Sarcoidosis Primary hyperparathyroidism Granulomatous diseases Malignancies Pregnancy Lactation

Locations (1)

Shiraz University of Medical Sciences

Shiraz, Fars, Iran

RECRUITING

Outcomes

Primary Outcomes

Urticaria symptom severity questionnaire after 1 week

Urticaria Symptom Severity ranging from 0 to 93

Time frame: 1 weeks

Secondary Outcomes

Urticaria symptom severity questionnaire after 6 week

Urticaria Symptom Severity ranging from 0 to 93

Time frame: 6 weeks

Urticaria symptom severity questionnaire after 12 week

Urticaria Symptom Severity ranging from 0 to 93

Time frame: 12 weeks

Central Contacts

Keramatallah Jahanshahi, MD

CONTACT

+989177416523 kjahanshahi91@gmail.com

Data from ClinicalTrials.gov

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