To evaluate the safety and effectiveness of cell therapy using precision cells Combined With TACE in Advanced Liver Cancer. Eligibility: Individuals greater than or equal to 18 years of age and less than or equal to 65 years of age who have been diagnosed with Advanced Liver Cancer.
A total of 40 patients may be enrolled over a period of 1-2 years.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Lipiodol 10-20ml,MMC 8~10mg,EADM20~ 40mg.According to tumor area of maximum diameter,0.1~0.2ml/cm2 Hepatic arterial infusion.
DC cell suspension (1×107 DC+ physiological saline \+ 0.25% human bloodalbumin) 1ml for each infusion, subcutaneous injection for each infusion 3 cycles, each cycle received two infusions on day 19, 20; 40, 41; 61, 62. Precision Cell suspension (1-6×109 PMAT/PNAT + physiological saline + 0.25% human bloodalbumin) 300ml for each infusion, IV (in the vein) for each infusion 3 cycles, each cycle received one infusions on day 21, 42, 63.
Ningbo No.5 Hospital (Ningbo Cancer Hospital)
Ningbo, Zhejiang, China
RECRUITINGOverall survival
Time frame: 2 years
Progress-free survival
Time frame: 2 years
Quality of life
Questionnaire will be used.
Time frame: 2 years
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