Crohn's disease goes along with an alteration of the quality of life, even in remission and has a negative impact on stress management linked to the pain and the health. Conversely, stress and psychological variables play a significant role in the pathogenesis of this disease. These interrelations reflects the link between the brain and the digestive tract, called brain-gut axis. The autonomic nervous system (ANS) is the neurological interface, relaying in a bidirectional way, informations between the digestive tract and the central nervous system (CNS). Visceral information can thus modulate the functionnement of CNS's areas involved in pain management but also in the management of emotional and cognitive behaviours. Yet, numerous work demonstrate the existence of a dysfunction of the ANS during Crohn's disease, with a dysautonomia of the sympatho-vagal balance. Human brain respond by advance before and during the application of a painful stimulus that enable the organism to regulate its nociceptive system in order to handle the aversive stimulus incoming, via the activation of brin areas managing the pain, or the raise of pain awareness. The uncertain and not predictable nature of a painful crisis and/or an inflammatory relapse in a chronic disease like Crohn's disease can be the origin of an anticipating apprehension and anxiety, that could influence visceral perception (increasing it). Nevertheless, only few studies exists about the differential role of certain or uncertain anticipation of the pain, despite the fact that they are associated to different emotional, cognitive and behavioral responses, and the effect of anticipation on painful visceral perception, have not yet been studied for parents in remission of Crohn's disease. The main goal is to search during certain and uncertain visceral anticipation, induced by distension of an intra-rectal balloon for persons suffering from Crohn's disease in remission, compared to control subjects, with an MRI functional study
Study Type
OBSERVATIONAL
Enrollment
44
Related to affective and cognitive dimensions of pain.
With a certain or uncertain anticipation phase of distension (warning light) followed or not by a rectal distension at the pain threshold previously determined, and then a retrospective quotation of pain during distension and the fear of pain induced by anticipation. Structural MRI and rest of functional connectivity measure MRI. With measure of heart rate variability.
During MRI session, from the electrocardiographic signal. (measure of variations on R-R interval in milliseconds ms).
UniversityHospitalGrenoble
La Tronche, France
RECRUITINGMagnetic Resonance Imaging
Activation of cortical cerebral structures involved in visceral pain and communication paths between them With a certain or uncertain anticipation phase of distension (warning light) followed or not by a rectal distension at the pain threshold previously determined, and then a retrospective quotation of pain during distension and the fear of pain induced by anticipation. Structural MRI and rest of functional connectivity measure MRI. With measure of heart rate variability.
Time frame: 30 minutes
Heart Rate Variability
During MRI session, from the electrocardiographic signal. (measure of variations on R-R interval in milliseconds ms).
Time frame: 30 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Questionnaire of personality inventory NEO-FFI (Bouvard, 2005)
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Questionnaire of depressive symptomatology CES-D (Center for Epidemiologic Studies-Depression Scale; Radloff, 1977)
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Anxiety inventory (STAI-Y of Spielberger)
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Pain Catastrophizing Scale of Sullivan 1995
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Pain Anxiety Symptoms Scale of Cracken 1992
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Fear of Pain Questionnaire of McNeil andRainwater ; 1998
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Visceral Sensitivity Index of Labus; 2004
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Questionnaire of Mindfulness, Walach 2006
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Questionnaire for uncertainty intolerance (Freeston 1994)
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : The Illness Attitude Scales, Dammen 1999
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Childhood Trauma Questionnaire of Bernstein 2003
Time frame: 45 minutes
Psychological tests
Related to affective and cognitive dimensions of pain : Ways of Coping Checklist Revised, adapted in French by Cousson 1996
Time frame: 45 minutes
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