Nocturnal/Diurnal Intraocular Pressure-Lowering Effect of Netarsudil Ophthalmic Solution

Inclusion Criteria: 1. 18 years of age or older. 2. Ocular hypertension or open-angle glaucoma in both eyes. 3. Unmedicated intraocular pressure \> 17 mmHg in one or both eyes and \< 30 mmHg in both eyes. 4. Corrected visual acuity in each eye equivalent to 20/200 or better. 5. Able and willing to give signed informed consent and follow study instructions. Exclusion Criteria: 1. Glaucoma with pseudoexfoliation or pigment dispersion component, history of angle closure, narrow angles. 2. Intraocular pressure ≥ 30 mmHg. 3. Use of ocular medications within 30 days. 4. Known hypersensitivity to any component of the test formulations or to medications used routinely during a clinical eye examination. 5. Previous eye surgery (other than cataract). 6. Ocular trauma within 6 months. 7. Clinically significant ocular disease that might interfere with the study. 8. Central corneal thickness greater than 620 µm.