Colorectal cancer (CRC) is a leading cause of cancer death and its' incidence is rising in most European countries. Colonoscopy has been shown to reduce CRC incidence, however its effectiveness depends on the sensitivity to detect pre-malignant lesions. Our aim is to evaluate narrow band imaging (NBI) during colonoscopy and serum miRNAs as novel tools for the early detection of colonic sessile serrated lesions (SSL). The investigators will perform a multicenter-randomized-controlled-trial to study the role of NBI in SSL detection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
987
colonoscope withdrawal and mucosal inspection performed under narrow band imaging
colonoscope withdrawal and mucosal inspection performed under white light imaging
Hospital Beatriz Ângelo
Loures, Portugal
RECRUITINGCentro Hospitalar do Porto
Porto, Portugal
NOT_YET_RECRUITINGInstituto Português de Oncologia do Porto
Porto, Portugal
NOT_YET_RECRUITINGaverage number of serrated lesions ≥10 mm detected per colonoscopy
Time frame: immediate
Serrated class lesions detection rate
number of patients with at least 1 lesion/total number of participants
Time frame: immediate
Serrated lesions <10 mm detected per colonoscopy
Time frame: immediate
SSL detection rate
histologically defined according to the WHO criteria
Time frame: immediate
Adenoma detection rate
number of patients with at least 1 adenoma/total number of participants
Time frame: immediate
Adenomas detected per colonoscopy
Time frame: immediate
Advanced (malignant) adenocarcinoma detection rate
Time frame: immediate
Incidence of procedure related adverse events
Time frame: immediate
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