Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock

Rush University Medical Center133 enrolled

Overview

Retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock.

This will be a retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock. The two cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or angiotensin-converting-enzyme inhibitor (ACE inhibitor) or 2) on a chronic β-blocker, on chronic ACE-Inhibitor, or on both chronic β-blocker and ACE-inhibitor

Study Type

OBSERVATIONAL

Enrollment

133

Conditions

Atrial Fibrillation Septic Shock

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients 18 years of age or older * Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin) * Admitted to the medical intensive care unit (MICU) at Rush University Medical Center (RUMC) * Time frame: 01/01/2012 to 07/1/2016 Exclusion Criteria: * Pregnant patients * Transfer from outside hospital on vasopressors * Admitted to MICU in cardiopulmonary arrest * Prior arrest within 24 hours of admission to RUMC

Locations (1)

Rush Univeristy Medical Center

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Cumulative percent (%) of patients with new onset atrial fibrillation at 48 hours

New onset atrial fibrillation defined as atrial fibrillation not present on admission to MICU

Time frame: 48 hours

Secondary Outcomes

Heart rate > 100

Total number of times with heart rate greater than 100 in 48 hours.

Time frame: 48 hours

New onset of other arrhythmias

Total onset of other arrhythmias not present on admission. Examples include, ventricular fibrillation, ventricular tachycardia, heart blocks, etc

Time frame: 48 hours

Peak lactate

Peak lactate level during the first 48 hours of admission

Time frame: 48 hours

Duration of mechanical ventilation

Time frame: During admission

In hospital mortality

Time frame: During admission

28 day mortality

Time frame: 28 days after discharge

90 day mortality

Time frame: 90 days after discharge

New onset atrial fibrillation for patients on other antiarrhythmics

Antiarrhythmic agents that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. Will include any single or combination of class I, II, III, IV antiarrhythmic agents

Data from ClinicalTrials.gov

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