The purpose of this study is to examine the effects of bile acid and bile acids sequestrants on GLP-1 Secretion, during a meal, in patients after Roux-en-Y gastric bypass.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
12
Hvidovre University Hospital
Hvidovre, Denmark
GLP-1 secretion (evaluated by iAUC)
Time frame: -10, 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes after mixed meal
Glucose levels
Time frame: -10, 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
Insulin secretion
Time frame: -10, 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
PYY secretion
Time frame: -10, 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
Bile acids/FGF19 concentrations
Time frame: -10, 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
Appetite measurements (VAS-score)
Time frame: 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
PCM levels
Time frame: Baseline, 0, 5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240 minutes
C-peptide secretion
Time frame: Baseline, 0, 5, 10, 20, 30, 45, 60, 90, 120, 180, 240 minutes
Glucagon secretion
Time frame: Baseline, 0, 10, 20, 30, 45, 60, 90, 120, 180, 240 minutes
GIP secretion
Time frame: 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
CCK secretion
Time frame: 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
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Ghrelin
Time frame: 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes
Total bile acid secretion
Time frame: 0, 10, 20, 30, 45, 60, 90, 120, 180 and 240 minutes