Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.

Assistance Publique - Hôpitaux de Paris53 enrolled

Overview

Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Obstructive Sleep Apnea

Interventions

Polysomnography , blood collection, bone densitometry and Functional respiratory explorationsOTHER

Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers "

Eligibility

Sex: MALEMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria Patient: * Men aged 20 to 65 years * Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil * With an AHI \> 5 / h Healthy volunteers: * Men aged 20 to 65 years * With an AHI ≤ 5 / h Exclusion Criteria All subjects: * Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated, * Known cardiovascular disease associated (heart failure, rhythm disorder ...) * Known respiratory diseases * Known neoplastic pathology, known chronic inflammatory disease * Psychiatric pathology treated * Medication * Not affiliated to the French social health care system * Major protected person * Private person of liberty * People in emergency situation * Patient refusing to participate in the study

Locations (1)

Henri Mondor Hospital

Créteil, France

Outcomes

Primary Outcomes

Telomere length of circulating leukocytes

Time frame: 4 weeks

Secondary Outcomes

Carotid-femoral pulse wave velocity

Time frame: 4 weeks

Bone density

Time frame: 4 weeks

Correlation between biological parameters and neuropsychological assessment

Time frame: 4 weeks

Markers of oxidative stress: Malondialdehyde, heme oxygenase-1

Time frame: 4 weeks

Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1

Time frame: 4 weeks

Markers of growth hormone axis (GH, IGF-1, IGFBP)

Time frame: 4 weeks

Data from ClinicalTrials.gov

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