The purpose is to evaluate if sodium fluoride PET in patients having already undergone a choline PET negative for bone extension (non-metastatic status) modifies the status of patients concerning the existence or not of bone metastases. Secondary purposes are: * To evaluate if detection of bone metastasis by sodium fluoride PET, not detected by choline PET, leads to change of treatment * To evaluate inter-technique concordance (choline vs sodium fluoride PET) of results (metastatic status and number of lesions) * To evaluate the inter-judge concordance of interpretation of sodium fluoride PET * To study the discordance of metastatic status of 2 techniques.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
110
Sodium fluoride Pet is realized maximum after 4 weeks from choline PET (inclusion). Injection of 4MBq 18F-FNa/kg of body weight is followed after 60 min (± 5 min) by acquisition of images on Biograph 6 PET/CT scanner (SIEMENS). Data from sodium fluoride PET are interpreted independently and blind from other data by 3 medical doctors (2 at hospital of Nancy and 1 at hospital of Strasbourg) (for inter-judge reproducibility); a second interpretation of data is consensually realized by 2 of 3 readers, limited to discordant analyses (metastatic status or not, and/or number of lesions); results from this second interpretation are final results.
Service de Médecine Nucléaire CHRU de Nancy-Brabois
Vandœuvre-lès-Nancy, France
RECRUITINGPercentage of patients with choline PET negative and sodium fluoride PET positive for bone extension (metastasis)
Time frame: Execution of sodium fluoride PET (up to 4 weeks from choline PET; from baseline up to 4 weeks)
Inter-strategy concordance of diagnosis evaluated by kappa coefficient
Concordance between results of choline PET and sodium fluoride PET
Time frame: Execution of sodium fluoride PET (up to 4 weeks from choline PET; from baseline up to 4 weeks)
Metastatic status and number of lesions detected respectively by sodium fluoride PET and choline PET
Time frame: Execution of sodium fluoride PET (up to 4 weeks from choline PET; from baseline up to 4 weeks)
Metastatic status and number of lesions identified by 3 medical doctors of 2 different centres in sodium fluoride PET
Time frame: Execution of sodium fluoride PET (from baseline up to 4 weeks)
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