The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children

University of Ghana547 enrolled

Overview

The aim of this study was to determine the effect of combining vitamin A (VA), zinc (Z) and multivitamins (MV- A, B1, B2, B6, B12, C, D and E) on malaria morbidity

A total of 542 children aged between 6-59 months received either: (i) VA (control) or (ii) VA \& Z (VAZ) or (iii) VA, Z \& MV (VAZM). VA was delivered as a single dose while MV and Z were delivered daily. Malaria cases were managed by community health workers, who used rapid diagnostic test to confirm infection prior to treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

547

Conditions

Malaria

Interventions

Vitamin ADIETARY_SUPPLEMENT

Vitamin A supplements

Vitamin A and ZIncDIETARY_SUPPLEMENT

Combination of vitamin A and zinc supplements

Vitamin A , Zinc and MultivitaminDIETARY_SUPPLEMENT

Combination of vitamin A, zinc and multivitamins

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * under 5years * will stay in the community for 10years Exclusion Criteria: * chronic diseases

Locations (1)

Amoako

Accra, Accra, Ghana

Outcomes

Primary Outcomes

Incidence of clinical malaria attacks

While taking the supplement, malaria incidence will be measured

Time frame: Baseline and every month up to six months

Secondary Outcomes

Incidence of diarrhea attacks

While taking the supplement, diarrhea incidence will be measured

Time frame: Every month up to six months

Data from ClinicalTrials.gov

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