The purpose is to search for enterocyte-specific or non-specific molecular signature of post-operating recurrence of Crohn's disease in transcriptome (measurement of gene expression through number of mRNA copies transcribed for each gene) and in methylome. Secondary objectives are to compare expression and methylation profiles according to: * treatment response * morphological (endoscopic and/or radiological) and clinical post-operating recurrence.
This aim of this study is to search for new biomarkers predictive of post-operating recurrence. At present, there are no biomarkers predictive for post-operating recurrence and administration of a post-operating medical treatment to prevent recurrence is based on biological, endoscopic and imagery data. Predictive biomarkers could allow the identification of patients with high risk of post-operating recurrence and administration of a systematic prophylactic post-operating treatment and at the same time avoiding the prescription of this treatment to patients with low risk of post-operating recurrence.
Study Type
OBSERVATIONAL
Enrollment
30
Gene expression profile in intestinal operative specimens
Time frame: up to 2 months (from resection)
Methylation profile in intestinal operative specimens
Time frame: up to 2 months (from resection)
Digestive symptoms
such as abdominal pain, Koenig syndrome (abdominal pain relieved by flatus or feces expulsion), diarrhea
Time frame: 6, 12, 24 months (after resection)
Radiological classification of recurrence with entero-MRI performed for post-operating follow-up of patients
Koilakou score, recurrence when score \>=1
Time frame: 6, 12, 24 months (after resection)
Evaluation of recurrence with endoscopy performed for post-operating follow-up of patients
Rutgeerts criteria (recurrence when score \>=i1)
Time frame: 6, 12, 24 months (after resection)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.