Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

CHU de Quebec-Universite Laval36 enrolled

Overview

This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.

Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anterior Uveitis Intermediate Uveitis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years old or more * anterior uncomplicated uveitis or intermediate uncomplicated uveitis Exclusion Criteria: * history of uveitis in the past, other than the actual uveitis * history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness * optic nerve or macular clinically apparent edema * history of glaucoma or other optic neuropathy * suspected or confirmed multiple sclerosis * ocular hypertension (intraocular pressure more than 22 mmHg) * reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT

Locations (1)

Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement. CHU de Québec

Québec, Canada

Outcomes

Primary Outcomes

Retinal Nerve Fiber Layer Thickness in anterior uveitis

Time frame: At time 0

Retinal Nerve Fiber Layer Thickness in intermediate uveitis

Time frame: At time 0

Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis

Time frame: at 4 to 6 weeks

Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis

Time frame: at 4 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.