Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients With Pseudomonas Aeruginosa

University Hospital, Lille1 enrolled

Overview

Rates of DMBT1 (Glycoprotein like) in Sputum of CF Patients with or without may be different according to their Pseudomonas Aeruginosa chronic colonization status. The aim of this study is to compare rates of DMBT1 (Glycoprotein like) in Sputum of CF patients with or without a Pseudomonas Aeruginosa chronic colonization.

Rates of DMBT1 (Deleted in Malignant Brain Tumor 1) will be compared between 2 groups of 30 CF patients : group 1 : with Pseudomonas Aeruginosa chronic colonization and group 2 30 CF patients without Pseudomonas Aeruginosa chronic colonization.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Malignant Brain Tumor

Eligibility

Sex: ALLMin age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CF patient 6 years * Availability of sputum * Signed Informed consent Exclusion Criteria: * Cardiac insufficiency * Anti-inflammatory drugs on going * Oral corticosteroid therapy * Inhaled corticosteroids during the two weeks before inclusion, * Patient awaiting lung transplantation * Patient with a past history of heart/lung transplantation * Patient with a sputum examination positive for : atypical mycobacteria, Burkholderia cepacia, Stenotrophomonas maltophilia, * Patient chronically colonized with multiresistant Pseudomonas aeruginosa * Orkambi© or Kalydeco© therapy * Change of the CF treatment during the last 4 weeks +/- 2 days before inclusion : corticosteroid, pancreatic extracts, antisecretory drugs...

Locations (1)

Hôpital Jeanne de Flandre - CHRU de Lille

Lille, France

Outcomes

Primary Outcomes

measure glycoprotein-like DMBT1 by Elisa

DMBT1 in mg DMBT1 / mg of total protein measured by BCA (BiCinchoninic acid Assay) present in each sputum

Time frame: at 1 months

Secondary Outcomes

measure MUC5B by Elisa

MUCB in mg / mg of total protein measured by BCA present in each sputum

Time frame: at 1 months

Data from ClinicalTrials.gov

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