Feasibility Study on LITT for Newly Diagnosed Glioblastoma

Relevant Inclusion Criteria: 1. Biopsy proven supratentorial GBM that has not undergone previous surgical resection, radiation and/or chemotherapy 2. Single enhancing lesion that is \>1 cm, but \< 4 cm in cross-sectional dimension, including thalamic tumor (≤ 3 cm) 3. The patient must be ≥18 years of age 4. KPS \> 70 5. Patients must have no concurrent malignancy except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix, breast, or bladder. Patients with prior malignancies must be disease-free for five years. 6. Stable cardiovascular, pulmonary health status Relevant Exclusion Criteria: 1. Seizures occurrence or the requirement of escalation (or addition) of anti-epileptic drugs 2. Symptoms due to mass effect of the tumor including high intracranial pressure, marked edema or ≥5mm midline shift significant 3. Uncontrolled cardiovascular conditions of hypertension (systolic \>180 mm Hg), angina pectoris, or cardiac dysrhythmia; or recent history of intracranial hemorrhage 4. Serious infection, immunosuppression or concurrent medical condition (chronic or acute in nature) that may prevent safe participation or ability to meet follow-up requirements 5. Pregnancy, or planning to become pregnant 6. Patients whose physical dimensions cannot be accommodated in the MRI scanner or patients with contraindications to MRI imaging such as pacemakers, non-compatible aneurysm clips, shrapnel and other internal ferromagnetic objects 7. Patients with multiple or multifocal GBM