Comparison of Two Neuromuscular Transmission Monitors Based on Acceleromyography: TOF-Watch SX® and TOFScan®

Central Hospital, Nancy, France142 enrolled

Overview

The purpose is to evaluate the reproducibility of neuromuscular monitoring data of recovery from neuromuscular blockade, obtained with TOFScan® and TOF-Watch SX®, in adult and pediatric population. Secondary purposes are to evaluate the reproducibility of data obtained with 2 monitors for: * the onset of clinical action of curare: suppression of the first response of train of four monitoring (T1) of 95% initial value * the duration of clinical action of curare: recovery of the first response of train of four monitoring (T1) to 25% initial value * recovery of first (T1), second (T2), third (T3) and fourth response (T4) of train of four monitoring, and recovery of T4/T1 to 40% and 60% initial value (T4/T1 0.4 and 0.6) * complete recovery from curarisation, at T4/T1=90% and T4/T1=100%.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

142

Conditions

Curarisation Neuromuscular Monitoring

Interventions

Eligibility

Sex: ALLMin age: 1 Year

Medical Language ↔ Plain English

Inclusion Criteria: Adult population: * Non opposition to research * \> 18 years old * ASA score 1-3 * Undergoing surgery with curarisation through tracheal intubation * Affiliation to social security Pediatric population: * \> 1 year old * Non opposition to research of child (if able to consent) or representatives with parental authority * ASA score 1-4 * Undergoing surgery with curarisation * Affiliation to social security Exclusion Criteria: Adult population: * Allergy to administered drugs * Known or suspected difficult intubation * Pregnant women * BMI \> 40 Pediatric population: * Allergy to administered drugs * Known or suspected difficult intubation

Outcomes

Primary Outcomes

Time of recovery of the first (T1) response of train of four monitoring displayed on TOFScan and on TOF Watch SX