The purpose of this research study is to evaluate if a weight loss intervention will improve your rheumatoid arthritis disease activity.
This is a pilot 12-week RCT (Randomized Clinical Trial) in 60 obese RA (Rheumatoid Arthritis) patients to evaluate if a weight loss intervention will improve PDUS (Power Doppler Ultra Sound), traditional disease activity measures (DAS28, Disease Activity Score - 28), and adipokine/MBDA (Multi-Biomarker Disease Activity) assessments. While there have been observational weight loss RA studies, none were RCTs and they did not utilize objective measures (PDUS or MBDA).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
40
Dietary supplement (protein drink) commercially available protein shakes
Dietary Counseling
recommendations for one meal per day including lean protein and vegetables
UCLA David Geffen School of Medicine, Division of Rheumatology
Los Angeles, California, United States
change in PDUS
Change in Synovitis measure using Ultrasound
Time frame: change from baseline to 6 and 12 months
change in DAS28
Change in DAS28 represents conventional measure of reduced disease activity
Time frame: change from baseline to 6 and 12 months
MBDA
Biomarker
Time frame: Baseline, 6 weeks and 12 weeks
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