Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients

Bangkok Metropolitan Administration Medical College and Vajira Hospital26 enrolled

Overview

The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

This cross -sectional study measured IL-6, procalcitonin and VEGF level in plasma and overnight effluent. PSTR of small solutes was evaluated by standard peritoneal equilibration test (standard PET). Weekly Kt/V and creatinine clearance (CCr ) were evaluated in all patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Kidney Disease

Interventions

Measure plasma and dialysate level of IL-6, procalcitonin and VEGFOTHER

correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Stable CAPD patients without previous history of peritonitis Exclusion Criteria: * HIV * Other infections, tuberculosis or on immunosuppressive drugs, * Autoimmune disease, * Cancer * Diagnosis of permanent ultrafiltration failure .

Locations (1)

Renal Unit, BMA Medical College and Vajira Hospital

Bangkok, Thailand

Outcomes

Primary Outcomes

plasma level of VEGF, IL-6 and procalcitonin with the PSTR and dialysis adequacy in CAPD patients

measure in pg/ml

Time frame: 2 years

Secondary Outcomes

Cytokines in diabetic and non-diabetic group

All cytokines in plasma and blood

Time frame: 2 years

Data from ClinicalTrials.gov

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