The general purpose of the trial is to investigate whether metformin is taken up into the breast tumor. Studies in the last few years have shown an effect of metformin on cell proliferation on breast cancer. It is though unclear whether the effect on tumor is direct, indirect or a combination of the two. The investigators plan to: * investigate if metformin is taken up in breast cancer using our novel 11C-metformin tracer and positron emission tomography (PET) * investigate whether the uptake is correlated to the amounts of organic cation transporters (OCT1-3, MATE 1 \&2 and PMAT) using quantitive polymerase chain reaction (qPCR).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
7
400MBq of 11C-metformin is injected in the cubital vein. The participant is then scanned for 120 min using Position Emission Tomography.
Department of Nuclear Medicine & PET-center, Aarhus University Hospital
Aarhus, Denmark
Department of Surgery, Aarhus University Hospital
Aarhus, Denmark
Metformin uptake in breast cancer
Time frame: 12 months
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