Dynamic Alterations of Th2/Th1 With New Onset of Community-acquired Severe Sepsis Patients

For community-acquired severe sepsis group: Inclusion Criteria: * at least 18 years of age and no more than 90 years of age * sepsis was defined according to consensus criteria * diagnosis of sepsis and complicatied with organ dysfunction no longer than 48 h * provided written informed consent. Exclusion Criteria: * diagnosis of hematological,immunological disease or cancer * treatment with chemotherapy agents or corticosteroids within 6 months prior to or during the hospitalization For non-severe sepsis ICU control group: Inclusion Criteria: * at least 18 years of age and no more than 90 years of age * without diagnosis of sepsis and admitted to ICU * provided written informed consent. Exclusion Criteria: * diagnosis of hematological,immunological disease or cancer * treatment with chemotherapy agents or corticosteroids within 6 months prior to or during the hospitalization For healthy control group: Inclusion Criteria: * at least 18 years of age and no more than 90 years of age * provided written informed consent. Exclusion Criteria: * diagnosis of hematological,immunological disease or cancer * treatment with chemotherapy agents or corticosteroids within 6 months prior to enrollment