Effects of Weight on Inflammation and Colon Cancer Risk

Tufts University43 enrolled

Overview

An observational study designed to compare colonic cytokine concentrations in lean versus obese individuals

An observational study was performed on 43 individuals undergoing routine screening colonoscopy, some of whom were lean and some who were obese. They had weight, height, and waist-hip ratio measured at the time of colonoscopy and had additional colonic biopsies to measure colonic cytokines.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Colorectal Cancer

Interventions

no interventionOTHER

there is no intervention in this study

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Caucasian 2. undergoing clinically-indicated screening colonoscopy 3. BMI\< or = 25, or 30+ Exclusion Criteria: 1. past history of cancer (except non-melanoma skin cancer) 2. a polyposis syndrome 3. any current or chronic inflammatory disease or infection 4. incapable of providing valid informed consent

Outcomes

Primary Outcomes

colonic concentration of Tumor Necrosis Factor-alpha

Time frame: time zero: at baseline

colonic concentration of Interleukin-6

Time frame: time zero: at baseline

colonic concentration of Interleukin-1 beta

Time frame: time zero: at baseline

colonic concentration of Interferon-gamma

Time frame: time zero: at baseline

Data from ClinicalTrials.gov

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