Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors

University of North Carolina, Chapel Hill34 enrolled

Overview

This study is observational only and is intended to evaluate changes in the makeup and function of bacteria naturally present in the mouth during treatment with braces to straighten teeth.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dental Caries Gingivitis

Eligibility

Sex: ALLMin age: 8 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I or II (ASA I is a healthy patient, ASA II is patient with minor systemic disease) * Patient must be receiving orthodontic treatment at the University of North Carolina School of Dentistry and not yet be in active treatment Exclusion Criteria: * Patients who have used antibacterial therapy in the past 3 months * Patients who report current smoking * ASA III or above (Patients with severe systemic diseases)

Locations (1)

UNC School of Dentistry

Chapel Hill, North Carolina, United States

Outcomes

Primary Outcomes

Change in Shannon diversity index from Baseline to Month 6

Time frame: Baseline, Month 6

Change from Baseline to Month 6 in Clusters Of Orthologous Groups of proteins

Time frame: Baseline, Month 6

Secondary Outcomes

Change in gingival index

Time frame: Baseline, Month 6

Change in decalcification index

Time frame: Baseline, Month 6

Data from ClinicalTrials.gov

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