Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD. The investigator would drive a study with a follow up of PD patients before and after STN-DBS. The pain will be clinically explored by targeted questionnaires and electrophysiological through laser evoked potentials. The questionnaires are designed to quantify and characterize the pain in these patients. Laser evoked potentials will, through repetitive stimulation, study both the functional status of the afferent nociceptive pathways, their habituation to repetitive nociceptive stimuli, and so better understand any abnormalities of the central processing of nociceptive information.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
26
Laser-Evoked potential can document lesions of spinothalamic tract and lateral brainstem and of thalamo-cortical projections conducting nociceptive signals. The rapid heating of skin by infrared laser pulses stimulate small fibers sensory pathways. The main cortical laser evoked potential is a complex of components N2-P2. Evaluation of the registered potentials includes shape, latency and amplitude.
Service de Neurologie C, Hôpital Neurologique, HCL
Bron, France
Modification of habituation in percentage, between tests performed before and after DBS
The habituation is the change of amplitude between the first and the second response of the double stimulation during the laser evoked potential. We calculated a percentage
Time frame: After the second laser evoked potential which occurred around 3 months after STN-DBS
Change in latency of laser evoked potential responses before and after DBS
latency is calculated in millisecond
Time frame: After the second laser evoked potential which occurred around 3 months after STN-DBS
Change in amplitude of laser evoked potential responses before and after DBS
amplitude is calculated in microvolts
Time frame: After the second laser evoked potential which occurred around 3 months after STN-DBS
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