Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly Diagnosed

Inclusion Criteria: * Male or female 18-65 years * Presenting focal epilepsy on the following arguments * Crisis with clinical symptoms indicating focal seizure * \& / Or crisis or critical focal inter-recorded on EEG interpreted by a neurologist with expertise in the field of epilepsy. * Having not yet received a CSF analysis * From unknown cause: * No evidence of injury (excluding temporal or hyperintensity of hippocampal sclerosis) on brain MRI with focus on regions of interest cuts. * No discharge or generalized photosensitivity recorded over an extended interpreted by a neurologist with expertise in the field of epilepsy video-EEG. * No argument for metabolic or neurodegenerative genetic epilepsy. * Normal neurological examination. * Epilepsy that started within a period of two years preceding the study entry (including vegetative symptoms of temporal focal seizures). * Without treatment or as benzodiazepines or taking anti-epileptic first-line monotherapy (excluding benzodiazepines). * Informed consent signed * affiliated with a social security scheme Exclusion Criteria: * structural abnormality found in brain MRI (except temporal hyperintensity and / or sclerosis of the hippocampus). * Background Neurological: hyperthermic seizures in childhood, neonatal distress, history of seizures related to a circumstance, inflammation or infection of the CNS. * Taking toxic: chronic alcoholism, narcotic consumption * The case for a genetic / metabolic neurodeg ear /: generalized EEG / photosensitivity / family history of epilepsy / autism / disorder syndrome psychomotor development / dysmorphic syndrome / extrapyramidal syndrome associated discharge * History of thyroiditis or m. system (LEAD, SGS, PR, Sarcoidosis) * Immunosuppression innate or acquired * IC lumbar puncture or have already received a lumbar puncture before inclusion in the protocol. * Person under supervision or guardianship.