The investigators examined the effects of 4-week dietary protein intake in mixed meals at two levels of protein amount on whole body glucose metabolisms in older adults with metabolic syndrome.
The investigators investigated changes in insulin sensitivity before and after 4 weeks of dietary intervention and control in subjects with metabolic syndrome. Two groups of subjects were studied before and after a weight maintenance diet. Group 1 was fed a common American diet with a macronutrient distribution of 10% protein, 55% carbohydrates, and 35% fat. Group 2 consumed a higher protein diet (20%; 1.4 g/kg/d of protein). Carbohydrate intake was lower in Group 2 (45%), with fat intake (largely derived from dairy sources) similar between groups. Glucose utilization and endogenous glucose production were determined during an oral glucose tolerance test (OGTT) with a novel double-tracer approach. The secondary aim was to determine the effect of a diet high in dairy consumption on blood lipid profiles. The investigators measured blood lipids before and after dietary intervention in each group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
12
Recommended protein intake diet contained 10% protein, 55% carbohydrate,and 35 % fat.
Recommended protein intake diet contained 20% protein, 45% carbohydrate,and 35 % fat.
Changes in rate of glucose disappearance
Rate of glucose disappearance from plasma to body tissues is a measure of whole body insulin sensitivity
Time frame: Change from baseline and after 4weeks of dietary intervention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.