Allogeneic Mesenchymal Human Stem Cells Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects

Inclusion Criteria: * Be ≥ 21 and \< 90 (inclusive) years of age. * Provide written informed consent. * Have endothelial dysfunction defined by impaired flow-mediated vasodilation (FMD \<7%). * Have an ejection fraction \> 45% by gated blood pool scan, two- dimensional echocardiogram, cardiac MRI, cardiac CT or left ventriculogram within the prior 3 months. * Have Diabetes mellitus type 2 documented by hemoglobin adult type 1 component (A1C) \> 7% or on medical therapy for diabetes. * Females of childbearing potential must use two forms of birth control for the duration of the study. Female subjects must undergo a blood or urine pregnancy test at screening and within 36 hours prior to infusion. Exclusion Criteria: In order to participate in this study, a subject Must Not: * Be younger than 21 years or older than 90 years of age. * Have a baseline glomerular filtration rate \<35 ml/min 1.73m\^2 estimated using the Modification of Diet in renal disease (MDRD) formula. * Have an ejection fraction \<45% by gated blood pool scan, two-dimensional echocardiogram, cardiac MRI, cardiac CT or left ventriculogram within the past year, as documented by medical history. * Have poorly controlled blood glucose levels with hemoglobin A1C \> 8.5%. * Have a history of proliferative retinopathy or severe neuropathy requiring medical treatment. * Have a hematologic abnormality as evidenced by hematocrit \< 25%, white blood cell \< 2,500/ul or platelet values \< 100,000/ul without another explanation. * Have liver dysfunction, as evidenced by enzymes (AST and ALT) greater than three times the upper limit of normal. * Have a bleeding diathesis or coagulopathy (INR \> 1.3), cannot be withdrawn from anticoagulation therapy, or will refuse blood transfusions. * Have Lymphadenectomy or Lymph node dissection in the right arm. * Be an organ transplant recipient or have a history of organ or cell transplant rejection. * Have a clinical history of malignancy within the past 5 years (i.e., subjects with prior malignancy must be disease free for 5 years), except curatively- treated basal cell or squamous cell carcinoma, or cervical carcinoma. * Have a condition that limits lifespan to \< 1 year. * Have a history of drug or alcohol abuse within the past 24 months. * Be on chronic therapy with immunosuppressant medication, such as corticosteroids or Tumor Necrosis Factor - alpha (TNFα) antagonists. * Be serum positive for HIV, Syphilis - VDRL (Confirmation with FTA-ABS if needed (Syphilis)), hepatitis B surface antigen or viremic hepatitis C. * Be currently participating (or participated within the previous 30 days) in an investigational therapeutic or device trial. * Be pregnant, nursing, or of childbearing potential while not practicing effective contraceptive methods. * Any other condition that in the judgment of the Investigator would be a contraindication to enrollment or follow-up.