Safety and Immunogenicity Study of Human Papilloma Virus Vaccine in Women Aged 9 to 30 and Men Aged 9 to 17

Inclusion Criteria: * Requirements of age: males of 9 to 17 years old, females of 9 to 30 years old. * Willing to provide the statutory certificate of identity. * For subjects of 18 to 30 years old, they should be able to understand the clinical trials and agreed to sign the informed consent; for subjects of 9 to 17 years old, their guardian should be able to understand the clinical trial, and sign informed consent together with subjects. * Female subjects have no pregnancy and birth plans in the 7 months after being enrolled, and agree to take effective contraception during this period. Exclusion Criteria: * People with history of cervical cancer or HPV infection related diseases such as condyloma * People with a history of severe allergic reactions requiring medical intervention (such as garget, difficult breathing, hypotension or shock) * People with a history of serious side effects after vaccination or severe allergic reaction to food or drugs * People with epilepsy or a history of mental illness * People in immune deficiency or diagnosed with congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia, systemic lupus erythematosus (SLE), rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), inflammatory bowel disease or other autoimmune diseases, people with immunosuppressive therapy in the past six months. * People with serious liver or kidney disease, cardiovascular disease, severe hypertension, diabetes, cancer, all kinds of infectious disease and acute disease or in acute attack period of chronic diseases * Asplenia, functional asplenia, and any situation leading to asplenia or splenectomize. * People diagnosed by doctors with coagulation dysfunction (such as the lack of clotting factors, disorders of blood coagulation and blood platelet disorders), apparent bruises or blood coagulation disorders; * People given whole blood, plasma or immunoglobulin therapy within 3 months before vaccination. * People get any vaccine within 14 days before the trial. * People with fever before vaccination, axillary temperature higher than 37.0 ℃. * Females in suckling period, pregnancy (pregnancy test positive) or prepared to be pregnant. * People with abnormal laboratory index. (slight abnormity is except if judged with no clinical significance by doctors.) * People has gotten HPV vaccine before; people has used or plans to use other vaccine or unregistered products (drugs or vaccines) within 30 days before the first dose; people plans to participate in other clinical trials within 6 months after this clinical trial. * According to judgement of researchers, the subjects have any other factors that are not appropriate for this clinical trials. The exclusion criteria for the second and third dose： * Urine pregnancy test are positive before vaccination. * Receiving blood products or other studied drugs after enrollment. * Suffering from serious illness or with serious adverse events that require continuous treatment. * Situations need to be excepted according to the judgement of researchers or the confirmation of Ethics Committee. * Newly occurred or discovered people that does not meet exclusion criteria of first dose after the first vaccination. Delayed immunization: * Acute infectious disease, temperature being over 37.0 ℃or acute attack of chronic disease before inoculation. * Physical examination is abnormal on the day of vaccination. * Researchers think that the subjects belong to other temporary contraindications of vaccination. Withdrawal criteria: * Any situation in exclusion criteria after enrollment. * People who suffers from diseases that need to be treated by immune inhibitors should be dropped out, in case of the harm of diseases that need to be treated by immune inhibitors. * Serious adverse events: events that need or prolong hospitalization, disability, threatening lives or death. Researchers decide whether to quit the trial. * Against the plan and deviation from the plan: 1. against the plan events * no appropriate informed consent for the subjects; * the subjects get into the research while do not meet the inclusion criteria or meet the exclusion criteria. * subjects use the vaccines that are not preserved as requested. * serious adverse event (SAE) does not be reported or timely reported. * subjects proactively use forbidden drugs (anti-allergic drug, antipyretic and analgesic, accepting systemic corticosteroids more than 2 mg/kg/day by intramuscular injection, oral or intravenous administration, continuing more than 14 days, or other immune inhibitors). 2. deviation from the plan * exceeding the Window of supervision. * the blood sample of subjects does not be collected or sample quantity is not enough to finish the test. * no enough interval with other vaccines.