The study is a prospective birth cohort study and the purpose is to describe the status of maternal key nutrients(eg. folate and vitamin D) supplementation among pregnancies at early gestation in Shanghai, to find out the association between the level of serum key nutrients and atopic dermatitis (AD) in offsprings during 6 months.
This study based on Shanghai pregnancy population is a prospective birth cohort. The investigators obtain the data of participants' folic acid and vitamin D supplement intake through the questionnaire at 12-14 gestational weeks. And the investigators collect participants' blood samples during gestation to directly detect the biological exposure levels of folate and vitamin D. In the follow-up, skin barrier function is evaluated at time of infant 24-48 hours, 42 days and 6 months. During 6 months from birth, the incidence of AD is investigated on offsprings. This cohort study is aimed to (1) clarify the association between prenatal key nutrients with offspring AD; (2) assess the role of maternal key nutrients in the skin barrier of offsprings. It will be a good evidence for the AD prevention and a meaningful protocol to reduce the incidence of AD by its unique design.Univariate and multivariate association analyses will be performed to identify risk factors to AD by using multivariate logistic regression model.
Study Type
OBSERVATIONAL
Enrollment
487
supplementation status and serum level
supplementation status and serum level
Children Hospital of Fudan University
Shanghai, China
Infant atopic dermatitis
Disease diagnosis according to the criteria of Williams
Time frame: incident of AD during 6 months after birth, diagnosis confirmed based on disease history till 12 months
Maternal RBC folate level
Whole blood sample collected will be used for evaluation
Time frame: 12-14 gestational weeks
Maternal serum vitamin D level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 12-14 gestational weeks
Maternal serum vitamin D level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 22-26 gestational weeks
Maternal serum vitamin D level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 34-36 gestational weeks
Maternal serum folate level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 12-14 gestational weeks
Maternal serum folate level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 22-26 gestational weeks
Maternal serum folate level
Serum sample collected at different trimesters will be used for evaluation
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Time frame: 34-36 gestational weeks
Maternal folic acid supplement intake
Questionnaire survey will be used to obtain the data of maternal supplement intake
Time frame: 12-14 gestational weeks
Maternal vitamin D supplement intake
Questionnaire survey will be used to obtain the data of maternal supplement intake
Time frame: 12-14 gestational weeks
Infant skin barrier function (Transepidermal Water Loss, TEWL）
TEWL will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 24-48 hours
Infant skin barrier function (Transepidermal Water Loss, TEWL）
TEWL will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 42 days old
Infant skin barrier function (Transepidermal Water Loss, TEWL）
TEWL will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 6 months old
Infant atopic dermatitis incidence by 1year old
Disease diagnosis according to the criteria of Williams
Time frame: from birth , to 12months old
Infant skin barrier function (Stratum corneum hydration, SCH)
SCH will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 24-48 hours
Infant skin barrier function (Stratum corneum hydration, SCH)
SCH will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 42 days old
Infant skin barrier function (Stratum corneum hydration, SCH)
SCH will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 6 months old
Infant skin barrier function (skin surface pH)
Skin pH will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 24-48 hours
Infant skin barrier function (skin surface pH)
Skin pH will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 42 days old
Infant skin barrier function (skin surface pH)
Skin pH will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 6 months old
Infant skin barrier function (sebum content)
Sebum content will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 24-48 hours
Infant skin barrier function (sebum content)
Sebum content will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 42 days old
Infant skin barrier function (sebum content)
Sebum content will be evaluated by the device of Multi Probe Adapter 4.
Time frame: infant 6 months old
Maternal serum Vitamin E level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 12-14 gestational weeks
Maternal serum Vitamin A level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 12-14 gestational weeks
Child atopic dermatitis from 1 year old to 2 years old
Disease diagnosis according to the criteria of Williams
Time frame: from 1 year old to 2 years old
Child atopic dermatitis from 2 years old to 5 years old
Disease diagnosis according to the criteria of Williams
Time frame: from 2 years old to 5 years old
Maternal serum fatty acid level
Serum sample collected at different trimesters will be used for evaluation
Time frame: 12-14 gestational weeks
Child atopic dermatitis from 5 years old to 8 years old
Disease diagnosis according to the criteria of Williams
Time frame: from 5 years old to 8 years old