This is a multicenter retrospective study in good prognosis Chinese patients. Data will be collected from infertile women who underwent first in vitro fertilization (IVF)/intra cytoplasmic sperm injection (ICSI) using a Gonadotropin releasing hormone (GnRH) antagonist (Cetrotide) protocol at about 4 IVF centers to investigate the factors associated with clinical pregnancy rate. The definition of the good prognosis subjects is, age not more than 35 years old, Baseline serum Follicle-stimulating hormone (FSH) level no more than 10 milliinternational units (mIU)/milliliter (ml), Body mass index (BMI) not more than 30 kilogram per meter square (kg/m\^2), previously underwent no more than 3 IVF/ICSI cycles, and the total dose of Gonadotropin used no more than 2500 IU in current cycle. No intervention(s) will be administered on the subjects. Data required to investigate the factors associated with the pregnancy outcome of GnRH antagonist IVF cycle will be collected from the subjects' medical records into database through electronic data capture system and analyzed.
Study Type
OBSERVATIONAL
Enrollment
3,000
This study will retrospectively collect the data from the subjects who had been treated with 0.25 mg of Cetrotide injection daily in a fixed or flexible antagonist protocol with an available ART outcome.
Peking University Third Hospital
Beijing, China
The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Reproductive Hospital Affiliated to Shandong University
Shandong, China
Reproductive & Genetic hospital of CITIC-XIANGYA
Xiangya, China
Clinical Pregnancy Rate
Number of clinical pregnancies expressed per 100 initiated cycles, aspiration cycles, and embryo transfer cycles. Initiated cycle: an assisted reproductive technology (ART) cycle in which the woman receives specific medication for ovarian stimulation, or monitoring in the case of natural cycles, with the intention to treat, irrespective of whether or not follicular aspiration is attempted. Aspiration cycle Initiated ART cycle in which one or more follicles are punctured and aspirated irrespective of whether or not oocytes are retrieved. Embryo transfer cycle: an ART cycle in which one or more embryos are transferred into the uterus or fallopian tube.
Time frame: 5 months
Implantation Rate
Implantation rate = (The number of gestational sacs observed divided by the number of embryos transferred)\*100
Time frame: 5 months
Ongoing Pregnancy Rate
Ongoing pregnancy rate per embryo transfer cycles = (Number of Ongoing pregnancy/Number of embryo transfer cycles)\*100 and ongoing pregnancy rate per initiated cycles = (Number of Ongoing pregnancy/Number of initiated cycles) \*100
Time frame: 5 months
Incidence and Severity of Ovarian Hyperstimulation Syndrome (OHSS)
Time frame: 5 months
Cycle Cancelled Rate
Cycle cancelled rate = (Number of subjects with terminated in vitro fertilization (IVF) or intra cytoplasmic sperm injection (ICSI) treatment/Number of initiated cycles)\*100
Time frame: 5 months
Early Miscarriage Rate
(Number of Early miscarriages/Number of clinical pregnancies)\*100
Time frame: 5 months
Live Birth Rate
Number of live births expressed per 100 initiated cycles, aspiration cycles or embryo transfer cycles. When delivery rates are given, the denominator (initiated, aspirated, or embryo transfer cycles) will be specified
Time frame: 5 months
Type of Gonadoptropin
Time frame: 5 months
Brand of Gonadotropin
Time frame: 5 months
Total Dose of Gonadotropin
Time frame: 5 months
Duration of Gonadotropin Administration
Time frame: 5 months
Cetrotide Start Day
Time frame: up to 5 months
Leading Follicle Size on the Day of Starting Cetrotide
Time frame: on the day of starting Cetrotide (up to 5 months)
Serum Luteinizing Hormone (LH) Level on the Day of Starting Cetrotide
Time frame: on the day of starting Cetrotide (up to 5 months)
Serum Estradiol (E2) Level on the Day of Starting Cetrotide
Time frame: on the day of starting Cetrotide (up to 5 months)
Serum Luteinizing Hormone (LH), Level on the Day of Human Chorionic Gonadotropin (hCG) Triggering
Time frame: 5 months
Serum Estradiol (E2) Level on the Day of Human Chorionic Gonadotropin (hCG) Triggering
Time frame: on the day of hCG triggering (up to 5 months)
Progesterone Level on the Day of Human Chorionic Gonadotropin (hCG) Triggering
Time frame: on the day of hCG triggering (up to 5 months)
Number of Follicles With Size 14 milimeter (mm) or More on the Day of Human Chorionic Gonadotropin (hCG) Triggering
Time frame: on the day of hCG triggering (up to 5 months)
Endometrial Thickness on the Day of Human Chorionic Gonadotropin (hCG) Triggering
Time frame: on the day of hCG triggering (up to 5 months)
Serum Luteinizing Hormone (LH) Level on the Day of Observed Premature Luteinizing Hormone (LH) Rise
Subjects will be characterized as having a premature LH rise if any measured LH value during follicular recruitment will more than (\>) 10 International Units Per Litre (IU/L) up to and including the day of the trigger
Time frame: on the day of observed premature LH rise (up to 5 months)
Serum Estradiol (E2) Level on the Day of Observed Premature Luteinizing Hormone (LH) Rise
Subjects will be characterized as having a premature LH rise if any measured LH value during follicular recruitment will more than (\>) 10 International Units Per Litre (IU/L) up to and including the day of the trigger
Time frame: on the day of observed premature LH rise (up to 5 months)
Serum Progesterone Level on the Day of Observed Premature Luteinizing Hormone (LH) Rise
Subjects will be characterized as having a premature LH rise if any measured LH value during follicular recruitment will more than (\>) 10 International Units Per Litre (IU/L) up to and including the day of the trigger
Time frame: on the day of observed premature LH rise (up to 5 months)
Number of Follicles With Size 14 mm or More on the Day of Observed Premature Luteinizing Hormone (LH) Rise
Subjects will be characterized as having a premature LH rise if any measured LH value during follicular recruitment will more than (\>) 10 International Units Per Litre (IU/L) up to and including the day of the trigger
Time frame: on the day of observed premature LH rise (up to 5 months)
Endometrial Thickness on the Day of Observed Premature Luteinizing Hormone (LH) Rise
Subjects will be characterized as having a premature LH rise if any measured LH value during follicular recruitment will more than (\>) 10 International Units Per Litre (IU/L) up to and including the day of the trigger
Time frame: on the day of observed premature LH rise (up to 5 months)
Serum Progesterone Level on the Day of Observed Premature Progesterone Rise
Premature progesterone rise: A rise in serum progesterone levels above 1.5 nanogram/milliliter (ng/ml) towards the end of the follicular phase up to and including the day of the trigger
Time frame: on the day of observed premature progesterone rise (up to 5 months)
Number of Oocytes Obtained
Time frame: 5 months
Number of Mature Metaphase II Oocytes Obtained
Time frame: 5 months
Fertilization Rate
Time frame: 5 months
Total Number of Embryos on Day 3/Blastocysts on Day 5
Time frame: Day 3 and Day 5
Number of Cryopreservation Embryos/Blastocysts on Day 3 or Day 5
Time frame: Day 3, Day 5
Number of Embryos/Blastocysts Transferred on Day 3 or Day 5
Time frame: Day 3, Day 5
Number of Good Quality Embryos/Blastocysts Transferred
Time frame: up to 5 months
Age
Time frame: Baseline
Duration of Infertility
Time frame: Baseline
Type of Infertility
Time frame: Baseline
Body Mass Index (BMI)
Time frame: Baseline
Smoking Status
Time frame: Baseline
Cause of Infertility
Time frame: Baseline
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